A 779 3TFA(159432-28-7(free base))

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A 779(3TFA) 是血管紧张素 (1-7) 受体的有效拮抗剂 A-779 抑制 Ang II 上调的增殖细胞核抗原 (PCNA) 蛋白表达，但单独使用 A-779 没有诱导增殖的作用和 VSMC 的迁移。

A 779(3TFA) is a potent antagonist of angiotensin-(1-7) receptor?A-779 suppresses the proliferating cell nuclear antigen (PCNA) protein expression up-regulated by Ang II, but A-779 alone has no effect to induce proliferation and migration of VSMCs.?Pretreatment with Ang-(1-7) significantly retards Ang II-induced inflammatory responses of VSMCs associated with up-regulated MCP-1, VCAM-1 and IL-1β expressions, and this effect of Ang-(1-7) is blocked by A-779.?But A-779 alone has no effect to induce inflammatory response of VSMCs.Inhibition of Ang1-7 cascade by A-779 significantly eradicated captopril protective effects on bone metabolism, mineralization and micro-structure.?A-779 also restored OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulated OPG expression and ACE-2/Ang1-7/Mas pathway.?In line with the clinical observations of the bone-preservative properties following ACE-1 inhibition, local activation of ACE-2/Ang1-7/Mas signaling and suppressed osteoclastogenesis seem responsible for the osteo-preservative effect of captopril, which could offers a potential therapeutic value in treatment of disabling bone and skeletal muscular diseases.

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Endocrinology/Hormones

RAAS

Angiotensin Receptor

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872.97

C39H60N12O11

>98% (HPLC)

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OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](C)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years